GHK-Cu

GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide-copper complex first isolated from human plasma. The peptide component — Gly-His-Lys — exhibits high affinity for cupric ions (Cu²⁺), forming a stable complex that has been identified in plasma, saliva, and urine across multiple species. GHK-Cu has been studied extensively in the context of copper-dependent enzymatic activity and its role in extracellular matrix biology.

Research programmes utilising GHK-Cu have investigated its effects in fibroblast culture systems, including assessments of collagen and glycosaminoglycan synthesis, matrix metalloproteinase modulation, and antioxidant enzyme expression. Additional in vitro studies have examined the compound’s interactions with gene expression networks related to tissue remodelling and inflammation response pathways. Its stability profile and defined coordination chemistry make it a well-characterised model compound for copper biology research.

Pepti-Genix supplies GHK-Cu as a lyophilised powder of ≥99% purity, independently verified by HPLC analysis. A Certificate of Analysis confirming identity and purity is included with every order. This compound is supplied strictly for in vitro laboratory research purposes only. It is not intended for human or veterinary use, consumption, injection, or administration of any kind.